Easier breathing
Lyprinol® intervenes in both inflammatory pathways by inhibiting the formation of leukotrienes, prostaglandins and thromboxanes. Leukotrienes are also the cause of bronchial asthma.
Asthma is a chronic respiratory disease and affects 15 to 17 percent of people.
Permanent inflammation of the respiratory ducts (bronchi) affects the flow of air in the lungs, making breathing difficult.
When allergens or irritants come into contact with inflamed bronchial tubes, they become even more constricted, constricted and, as a result, excessive respiratory reaction, making breathing difficult.
Asthma should be treated by a specialist pulmonologist.
ABSTRACT
Managing asthma with the lipid extract of a New Zealand green-shell
(Randomized clinical trial); Emelyanov, G. Fedoseev, O. Krasnoschekova, A. Abulimity, T. Trendeleva, P.J. Barnes
Asthma is a chronic inflammatory respiratory disease that is at least partially triggered by leukotrienes and other inflammatory mediators.
Experimental studies have shown that the lipid extract of the New Zealand green oyster shell "Perna Canaliculus" is effective in inhibiting the 5-lipoxygenase and cyclooxygenase pathways responsible for the formation of ecososanoids, including leukotrienes and prostaglandins.
The aim of this double-blind, randomized, placebo-controlled clinical trial was to evaluate the effect on symptoms, peak airflow during exhalation (PEF) and hydrogen peroxide (H2O2) in exhaled air condensate as a marker of respiratory inflammation in patients with atopic asthma not yet treated with steroids.
46 patients with atopic asthma received 2 capsules of lipid extract Lyprinol or placebo twice daily for eight weeks.
Each capsule of Lyprinol contained 50 mg of polyunsaturated omega 3 fatty acids and 100 mg of olive oil, while placebo contained only 150 mg of olive oil.
In the Lyprinol® group, a significant decrease in daytime wheezing, concentration of exhaled H2O2, and an increase in morning PEF were observed compared with placebo. There were no significant side effects.
REFERENCES
Whitehouse MW, Macrides TA, Kalfatis NK, Betts WH, Haynes DR, Broadbent J.Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel Inflammopharmacology1997 Vol. 5 pp. 237–2462.
Rainsford KD, Whitehouse MW. Gastroprotective and anti-inflammatory properties of green-lipped mussel (Perna canaliculus) preparation Arzn Forsch1980 Vol. 30 str. 2128–21323. Halpern G-M.Anti-inflammatory effects of a stabilized lipid extract of Perna Canaliculus(Lyprinol®) Allerg Immunol (Paris)2000 Vol. 32 str. 272–2784.
Sinclair AJ, Murphy KJ, Li D. Marine lipids: overview “news insights and lipid composition of Lyprinol” Allerg Immunol (Paris)2000 Vol. 32 str. 261–2715.
Gibson SLM, Gibson RG.The treatment of arthritis with lipid extract of Perna canaliculus: a randomized trial Compl Ther Med1998 Vol. 6 str. 122–1266.
Gibson RG, Gibson S, Conway V, Chappel D. Perna canaliculusin the treatment of arthritis Practitioner1980 Vol. 224 str. 955–9607.
American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma Am Rev Respir Dis1987 Vol. 136 str. 225–2448.
Diagnosis and classificationIn: Global Initiative for asthma. NHLB/WHO Workshop Report. Publication number 95]3659USA, National Heart Lung Blood Institute, 1995; str. 48–61.9. Emelyanov A, Fedoseev G, Abulimity A. et al.Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients Chest2001 Vol. 120 str. 1136–113910.
Gallati H, Pracht I. Horseradish peroxidase: kinetic studies and optimisation of peroxide activity determination using the substrates H2O2and 3,3´,5,5´-tetramethybenzidine J Clin Chem Clin Biochem1985 Vol. 23 str. 453–46011.
Endres S, Ghorbani R, Kelly VE. et al.The effect of dietary supplementation with v-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells N Engl J Med1989 Vol. 320 str. 265–27112.
Kromann N, Green A.Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950]1974 Acta Med Scan1980 Vol. 208 str. 401–40613.
Schwartz J, Weiss ST.The relationship of dietary fish oil intake to level of pulmonary function in the first National Health and Nutritional Survey Eur Respir J1994 Vol. 7 str. 1821–182414.
Peat JK, Salome CM, Woolcock AJ. Factors associated with bronchial hyperresponsiveness in Australian adults and children Eur Respir J1992 Vol. 5 str. 921–92915.
Satomi H, Minowa M, Hatano S, Iikura Y. An epidemiological study of the preventive effect of dietary fish on bronchial asthma Bull Inst Public Health1994 Vol. 43 str. 305–31416.
Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. Dietary supplementation with fish oil rich in v-3 polyunsaturated fatty acids in children with bronchial asthma Eur Respir J2000 Vol. 16 str. 861–86517. Piper PJ.Leukotrienes: potent mediators of airway constriction Int Arch Allergy Appl Immunol1985 Vol. 76 Suppl. 1, str. 43–4818.
Wang CG, Du T, Xu LJ, Martin JG. Role of leukotriene D4in allergen-induced increases in airway smooth muscle in rat Am Rev Respir Dis1994 Vol. 148 str. 413–41719.
Marom Z, Shelhamer JH, Bach MK, Morton DR, Kaliner M. Slow-reacting substances leukotriene C4and D4, increase the release of mucus from human airway in vitro Am Rev Respir Dis1982 Vol. 126 str. 449–45120.
Dahlen S-E, Bjorck, Heaqvist P. et al.Leukotrienes promote plasma leakage and leukocyte adhesion in post-capillary venules: in vitroeffects with relevance to the acute inflammatory response Proc Natl Acad Sci USA1981 Vol. 78 str. 3887–389121.
Laitinen LA, Laitinen A, Haahtela T, Vilkka V, Spur BW, Lee TH. Leukotriene E4cause granulocyte infiltration into asthmatic airway Lancet1993 Vol. 341 str. 989–99022.
Mates JM, Sanchez-Jimenez F. Antioxidant enzymes and their implications in pathophysiologic processes Front Biosci1999 Vol. 4 str. 339–34523.
Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary diseases Am J Respir Crit Care Med2001 Vol. 163 str. 1693–172224.
Antzak A, Nowak D, Shariati B, Krol M, Piasecka G, Kurmanowska Z. Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients Eur Respir J1997 Vol. 9 str. 1235–124125.
Horvath I, Donnely LE, Kiss A. et al.Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma Am J Respir Crit Care Med1998 Vol. 158 str. 1042–104626.
Antzak A, Nowak D, Bialasiewicz P, Kasielski M. Hydrogen peroxide in expired air condensate correlates positively with early steps of peripheral neutrophil activation in asthmatic patients Arch Immunol Ther Exp (Warsz)1999 Vol. 47 str. 119–126
Asthma is a chronic respiratory disease and affects 15 to 17 percent of people.
Permanent inflammation of the respiratory ducts (bronchi) affects the flow of air in the lungs, making breathing difficult.
When allergens or irritants come into contact with inflamed bronchial tubes, they become even more constricted, constricted and, as a result, excessive respiratory reaction, making breathing difficult.
Asthma should be treated by a specialist pulmonologist.
ABSTRACT
Managing asthma with the lipid extract of a New Zealand green-shell
(Randomized clinical trial); Emelyanov, G. Fedoseev, O. Krasnoschekova, A. Abulimity, T. Trendeleva, P.J. Barnes
Asthma is a chronic inflammatory respiratory disease that is at least partially triggered by leukotrienes and other inflammatory mediators.
Experimental studies have shown that the lipid extract of the New Zealand green oyster shell "Perna Canaliculus" is effective in inhibiting the 5-lipoxygenase and cyclooxygenase pathways responsible for the formation of ecososanoids, including leukotrienes and prostaglandins.
The aim of this double-blind, randomized, placebo-controlled clinical trial was to evaluate the effect on symptoms, peak airflow during exhalation (PEF) and hydrogen peroxide (H2O2) in exhaled air condensate as a marker of respiratory inflammation in patients with atopic asthma not yet treated with steroids.
46 patients with atopic asthma received 2 capsules of lipid extract Lyprinol or placebo twice daily for eight weeks.
Each capsule of Lyprinol contained 50 mg of polyunsaturated omega 3 fatty acids and 100 mg of olive oil, while placebo contained only 150 mg of olive oil.
In the Lyprinol® group, a significant decrease in daytime wheezing, concentration of exhaled H2O2, and an increase in morning PEF were observed compared with placebo. There were no significant side effects.
REFERENCES
Whitehouse MW, Macrides TA, Kalfatis NK, Betts WH, Haynes DR, Broadbent J.Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel Inflammopharmacology1997 Vol. 5 pp. 237–2462.
Rainsford KD, Whitehouse MW. Gastroprotective and anti-inflammatory properties of green-lipped mussel (Perna canaliculus) preparation Arzn Forsch1980 Vol. 30 str. 2128–21323. Halpern G-M.Anti-inflammatory effects of a stabilized lipid extract of Perna Canaliculus(Lyprinol®) Allerg Immunol (Paris)2000 Vol. 32 str. 272–2784.
Sinclair AJ, Murphy KJ, Li D. Marine lipids: overview “news insights and lipid composition of Lyprinol” Allerg Immunol (Paris)2000 Vol. 32 str. 261–2715.
Gibson SLM, Gibson RG.The treatment of arthritis with lipid extract of Perna canaliculus: a randomized trial Compl Ther Med1998 Vol. 6 str. 122–1266.
Gibson RG, Gibson S, Conway V, Chappel D. Perna canaliculusin the treatment of arthritis Practitioner1980 Vol. 224 str. 955–9607.
American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma Am Rev Respir Dis1987 Vol. 136 str. 225–2448.
Diagnosis and classificationIn: Global Initiative for asthma. NHLB/WHO Workshop Report. Publication number 95]3659USA, National Heart Lung Blood Institute, 1995; str. 48–61.9. Emelyanov A, Fedoseev G, Abulimity A. et al.Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients Chest2001 Vol. 120 str. 1136–113910.
Gallati H, Pracht I. Horseradish peroxidase: kinetic studies and optimisation of peroxide activity determination using the substrates H2O2and 3,3´,5,5´-tetramethybenzidine J Clin Chem Clin Biochem1985 Vol. 23 str. 453–46011.
Endres S, Ghorbani R, Kelly VE. et al.The effect of dietary supplementation with v-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells N Engl J Med1989 Vol. 320 str. 265–27112.
Kromann N, Green A.Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950]1974 Acta Med Scan1980 Vol. 208 str. 401–40613.
Schwartz J, Weiss ST.The relationship of dietary fish oil intake to level of pulmonary function in the first National Health and Nutritional Survey Eur Respir J1994 Vol. 7 str. 1821–182414.
Peat JK, Salome CM, Woolcock AJ. Factors associated with bronchial hyperresponsiveness in Australian adults and children Eur Respir J1992 Vol. 5 str. 921–92915.
Satomi H, Minowa M, Hatano S, Iikura Y. An epidemiological study of the preventive effect of dietary fish on bronchial asthma Bull Inst Public Health1994 Vol. 43 str. 305–31416.
Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. Dietary supplementation with fish oil rich in v-3 polyunsaturated fatty acids in children with bronchial asthma Eur Respir J2000 Vol. 16 str. 861–86517. Piper PJ.Leukotrienes: potent mediators of airway constriction Int Arch Allergy Appl Immunol1985 Vol. 76 Suppl. 1, str. 43–4818.
Wang CG, Du T, Xu LJ, Martin JG. Role of leukotriene D4in allergen-induced increases in airway smooth muscle in rat Am Rev Respir Dis1994 Vol. 148 str. 413–41719.
Marom Z, Shelhamer JH, Bach MK, Morton DR, Kaliner M. Slow-reacting substances leukotriene C4and D4, increase the release of mucus from human airway in vitro Am Rev Respir Dis1982 Vol. 126 str. 449–45120.
Dahlen S-E, Bjorck, Heaqvist P. et al.Leukotrienes promote plasma leakage and leukocyte adhesion in post-capillary venules: in vitroeffects with relevance to the acute inflammatory response Proc Natl Acad Sci USA1981 Vol. 78 str. 3887–389121.
Laitinen LA, Laitinen A, Haahtela T, Vilkka V, Spur BW, Lee TH. Leukotriene E4cause granulocyte infiltration into asthmatic airway Lancet1993 Vol. 341 str. 989–99022.
Mates JM, Sanchez-Jimenez F. Antioxidant enzymes and their implications in pathophysiologic processes Front Biosci1999 Vol. 4 str. 339–34523.
Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary diseases Am J Respir Crit Care Med2001 Vol. 163 str. 1693–172224.
Antzak A, Nowak D, Shariati B, Krol M, Piasecka G, Kurmanowska Z. Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients Eur Respir J1997 Vol. 9 str. 1235–124125.
Horvath I, Donnely LE, Kiss A. et al.Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma Am J Respir Crit Care Med1998 Vol. 158 str. 1042–104626.
Antzak A, Nowak D, Bialasiewicz P, Kasielski M. Hydrogen peroxide in expired air condensate correlates positively with early steps of peripheral neutrophil activation in asthmatic patients Arch Immunol Ther Exp (Warsz)1999 Vol. 47 str. 119–126
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